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helix b surface peptide hbsp  (Mimetics)

 
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    Structured Review

    Mimetics helix b surface peptide hbsp
    Schematic overview of erythropoietin (EPO) and engineered derivatives in traumatic brain injury (TBI). The diagram illustrates phase-specific mechanisms by which EPO and its engineered derivatives (carbamylated EPO, asialo-EPO, darbepoetin alfa, and <t>HBSP/cibinetide)</t> mitigate secondary brain injury. HBSP and CEPO are βcR-biased ligands that preferentially activate cytoprotective PI3K–AKT and NF-κB pathways, whereas darbepoetin alfa retains STAT5 signaling associated with erythropoiesis. Color coding: orange = JAK2/STAT5; blue = PI3K/AKT; teal = MAPK/ERK; purple = INPP5D/NF-κB.
    Helix B Surface Peptide Hbsp, supplied by Mimetics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/helix+b+surface+peptide+hbsp/alpha+helix+inducers+non+peptide/pmc12875903-70-19-3
    Average 86 stars, based on 1 article reviews
    helix b surface peptide hbsp - by Bioz Stars, 2026-10
    86/100 stars

    Images

    1) Product Images from "Phase-targeted erythropoietin derivatives for traumatic brain injury: bridging mechanisms to precision therapy"

    Article Title: Phase-targeted erythropoietin derivatives for traumatic brain injury: bridging mechanisms to precision therapy

    Journal: Frontiers in Neurology

    doi: 10.3389/fneur.2025.1665405

    Schematic overview of erythropoietin (EPO) and engineered derivatives in traumatic brain injury (TBI). The diagram illustrates phase-specific mechanisms by which EPO and its engineered derivatives (carbamylated EPO, asialo-EPO, darbepoetin alfa, and HBSP/cibinetide) mitigate secondary brain injury. HBSP and CEPO are βcR-biased ligands that preferentially activate cytoprotective PI3K–AKT and NF-κB pathways, whereas darbepoetin alfa retains STAT5 signaling associated with erythropoiesis. Color coding: orange = JAK2/STAT5; blue = PI3K/AKT; teal = MAPK/ERK; purple = INPP5D/NF-κB.
    Figure Legend Snippet: Schematic overview of erythropoietin (EPO) and engineered derivatives in traumatic brain injury (TBI). The diagram illustrates phase-specific mechanisms by which EPO and its engineered derivatives (carbamylated EPO, asialo-EPO, darbepoetin alfa, and HBSP/cibinetide) mitigate secondary brain injury. HBSP and CEPO are βcR-biased ligands that preferentially activate cytoprotective PI3K–AKT and NF-κB pathways, whereas darbepoetin alfa retains STAT5 signaling associated with erythropoiesis. Color coding: orange = JAK2/STAT5; blue = PI3K/AKT; teal = MAPK/ERK; purple = INPP5D/NF-κB.

    Techniques Used:

    Related Articles

    Derivative Assay:

    Article Title: Phase-targeted erythropoietin derivatives for traumatic brain injury: bridging mechanisms to precision therapy
    Article Snippet: .. Peptide truncation and mimetics : Efforts to minimize molecule size while retaining function have led to the development of helix-B surface peptide (HBSP) and EPObis, short synthetic peptides derived from the EPO binding interface ( , ). ..

    Binding Assay:

    Article Title: Phase-targeted erythropoietin derivatives for traumatic brain injury: bridging mechanisms to precision therapy
    Article Snippet: .. Peptide truncation and mimetics : Efforts to minimize molecule size while retaining function have led to the development of helix-B surface peptide (HBSP) and EPObis, short synthetic peptides derived from the EPO binding interface ( , ). ..



    Similar Products

    helix b surface peptide hbsp  (Mimetics)
    86
    Mimetics helix b surface peptide hbsp
    Schematic overview of erythropoietin (EPO) and engineered derivatives in traumatic brain injury (TBI). The diagram illustrates phase-specific mechanisms by which EPO and its engineered derivatives (carbamylated EPO, asialo-EPO, darbepoetin alfa, and <t>HBSP/cibinetide)</t> mitigate secondary brain injury. HBSP and CEPO are βcR-biased ligands that preferentially activate cytoprotective PI3K–AKT and NF-κB pathways, whereas darbepoetin alfa retains STAT5 signaling associated with erythropoiesis. Color coding: orange = JAK2/STAT5; blue = PI3K/AKT; teal = MAPK/ERK; purple = INPP5D/NF-κB.
    Helix B Surface Peptide Hbsp, supplied by Mimetics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/helix+b+surface+peptide+hbsp/alpha+helix+inducers+non+peptide/pmc12875903-70-19-3
    Average 86 stars, based on 1 article reviews
    helix b surface peptide hbsp - by Bioz Stars, 2026-10
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    Schematic overview of erythropoietin (EPO) and engineered derivatives in traumatic brain injury (TBI). The diagram illustrates phase-specific mechanisms by which EPO and its engineered derivatives (carbamylated EPO, asialo-EPO, darbepoetin alfa, and HBSP/cibinetide) mitigate secondary brain injury. HBSP and CEPO are βcR-biased ligands that preferentially activate cytoprotective PI3K–AKT and NF-κB pathways, whereas darbepoetin alfa retains STAT5 signaling associated with erythropoiesis. Color coding: orange = JAK2/STAT5; blue = PI3K/AKT; teal = MAPK/ERK; purple = INPP5D/NF-κB.

    Journal: Frontiers in Neurology

    Article Title: Phase-targeted erythropoietin derivatives for traumatic brain injury: bridging mechanisms to precision therapy

    doi: 10.3389/fneur.2025.1665405

    Figure Lengend Snippet: Schematic overview of erythropoietin (EPO) and engineered derivatives in traumatic brain injury (TBI). The diagram illustrates phase-specific mechanisms by which EPO and its engineered derivatives (carbamylated EPO, asialo-EPO, darbepoetin alfa, and HBSP/cibinetide) mitigate secondary brain injury. HBSP and CEPO are βcR-biased ligands that preferentially activate cytoprotective PI3K–AKT and NF-κB pathways, whereas darbepoetin alfa retains STAT5 signaling associated with erythropoiesis. Color coding: orange = JAK2/STAT5; blue = PI3K/AKT; teal = MAPK/ERK; purple = INPP5D/NF-κB.

    Article Snippet: Peptide truncation and mimetics : Efforts to minimize molecule size while retaining function have led to the development of helix-B surface peptide (HBSP) and EPObis, short synthetic peptides derived from the EPO binding interface ( , ).

    Techniques: